Biotechnology

Experimental Development in Biotechnology

An additional company focus is biotechnology development. For over 12 years, the company has invested in development and research to create a technical base for in vitro eukaryotic cell propagation using automated systems and developing cell propagation technological processes. This base created three sub-directions: obtaining bioactive substances released during cell cultivation and accumulated in cultivation medium; large-scale cell propagation for potential pharmaceutical applications; and development of new automated cell cultivation systems.

Bioactive Substance Extraction

Cells release many different bioactive substances during their lifetime, serving as signals or ensuring tissue functioning, communication, and response to environmental influences. By cultivating cells under controlled conditions, it’s possible to simulate specific conditions, forcing the particular cell population to release bioactive substances. Using this principle, it’s possible to obtain bioactive substances usable in skin regeneration products.

In Vitro Cell Propagation

With the development of new treatment methods based on human cell and tissue use, the industry faced the problem of therapeutic cell availability. Cell quantities obtained from patient biopsies were often insufficient for expected therapeutic results, and their varying amounts complicated clinical effect assessment. Industry demand emerged for equipment to propagate various cells outside the human body to ensure specific concentrations and perform multi-stage procedures.

Main challenges were creating processes maximally similar to human body processes and obtaining sufficient high-quality product volume.

Cell Cultivation System Development

Automated cell cultivation systems are essential prerequisites for product development and raw material acquisition. Historically, eukaryotic cell cultivation used specialized laboratory vessels that, due to their construction and effective cultivation surface area, couldn’t provide sufficient infection protection and were relatively inefficient. With demand for large-scale cell propagation, solutions were sought to significantly increase cultivation surface in small volumes and reduce contamination risks. The company develops conceptual solutions for large-scale adherent cell propagation reactor systems and process automation.